TRIAD: Treatment of insomnia and depression is seeking volunteers

TRIAD Study information

Contact Us

Study Coordinator: Haddas Elisha

(650) 723-2641 |

This study is no longer recruiting participants.


Depression and insomnia are often experienced simultaneously.

It is difficult to deal with depression when you are not getting enough sleep. It is also difficult to sleep when you are feeling especially upset, empty, down or sad. Antidepressant medications and psychotherapy for depression are helpful for reducing overall depression but often do not cure insomnia.Insomnia therapies can effectively improves sleep in individuals with sleep difficulties and might improve mood but usually do not cure depression.

We hope to improve the treatment of individuals with depression and insomnia.

Our Research

The TRIAD team tests if combining antidepressant medications and insomnia therapy will improve the lives of people who experience both conditions simultaneously.

What does the study entail?

Participants who are eligible for the TRIAD study receive 16 weeks of treatment with an antidepressant medication AND seven sessions of psychotherapy for insomnia. 

Eligibility will be determined based on clinical assessments and an all night sleep study

Who is eligible?

TRIAD is open to adults, ages 18 to 75, who are medically stable.  Interested participants will be screened for eligibility.

Screening for the study includes an at-home, all-night sleep study as well as interviews to ascertain eligibility, including a comprehensive assessment of sleep disorders.

Potential Benefits

  • Participants will receive treatments that may improve depression and/or sleep
  • Participants will receive feedback about the results of an overnight sleep study and other assessments.
  • Participation may provide the investigators valuable data that may lead to advances in the understanding and treatment of individuals with depression and insomnia.  It may ultimately lead to broader benefits for society and for persons who are afflicted with a similar condition.


Relevant links with information about:



About Depression

Some symptoms of depression are:

  • feeling sad, unhappy, empty, or helpless
  • low energy, fatigue, lack of motivation
  • eating too little or too much
  • enjoying activities less than usual
  • difficulty concentrating
  • feeling worthless or guilty
  • trouble falling asleep or staying asleep
  • very low energy

How can I reach the study?

This study is no longer recruiting participants. For other questions, you can reach the study coordinator at (650) 723-2641.

Where the study is conducted?

This study is conducted at the Stanford School of Medicine Department of Psychiatry and Behavioral Sciences.

Who is funding the study?

The study is funded by the National Institutes of Mental Health (NIMH).